Appalachia is modeled on West Virginia and features recreations of many real locations. The whole world of the game is divided into six regions with different climate and enemy levels: The Forest, The Ash Heap, Cranberry Bog, Toxic Valley, Savage Divide and The Mire.

Sewers x2, Treasure Map Locations x35, Unique Location x1, Unique Location x1, Unique Location x1, Unique Location x1, Unique Location x1, Unique Location x1, Unique Location x1, Unique Location x1, Unique Location x1, Unique Location x1, Unique Location x1, Unique Location x1, Unique Location x1, Unique Location x1, Unique Location x1, Unique Location x1, Unique Location x1, Vault x1, Vault x1, Vault x1, Vault x1, Public Workshops x22, Elevated Highway x2, Compound x4, Railroad x2, Piers x2, Filling Stations x2, Mansions x6, Graveyards x3, Golf Clubs x3, Trailers x7, Forested x8, Landmarks x2, Electrical Substations x8, Radioactive x3, Satellite x3, Aviation x3, Raider Settlements x11, Ponds x11, Amusement Parks x4, Camps x5, Lookouts x13, Cities x3, Towns x14, Bunkers x14, Town Ruins x5, Radio Towers x8, Caverns x7, Overlooks x6, Dams x2, Industrial x10, Farms x14, Military Bases x12, Brownstone x10, Train Stations x12, Train Tracks x5, Shack x11, Cabins x18, Quarries x19, Low Rise x8, Medical x2, Power Plants x3, High Tech Buildings x14, Ski Resorts x4, Monuments x2, Fissure Sites x9, Other x12
An alphabetical list of quests that begin on this map.
The following legend of Appalachia / West Virginia interactive game map defines the points of interest / markers displayed on the map. Each marker corresponds to a specific element to facilitate efficient navigation and interaction with the map.
Every Train Station scattered throughout Appalachia has at least one vendor and a Stash Box.