To start this quest you need to talk to Spirit of the Black Widowmaker.
We communed with the spirit of a lizard called the Black Widowmaker - a renowned Lone Wolf poisoner. He himself was tricked into consuming poison by a fellow Lone Wolf, Snakeroot. He wants her dead.

1. Killed Wolf
Kill Snakeroot.
Snakeroot is dead. The spirit of the Black Widowmaker will be satisifed, no doubt.

2. Got Reward
Talk to Spirit of the Black Widowmaker after killing Snakeroot.
His killer vanquished, the spirit of the Black Widowmaker departed for the Hall of Echoes.
3. Ghost Sucked
The spirit of the Black Widowmaker's Source was consumed.
4. Close Left RC
We have sailed on from Reaper's Coast, without helping the spirit of the Black Widowmaker.