In Resident Evil Requiem, Safes are locked containers you find in various areas of the game that require a combination code to open. To open a safe, you must enter the correct combination by rotating the dial left or right to the required numbers before confirming the code. The combinations are usually learned by finding associated Files or notes scattered in the environment, though once you know them you can open the safes without reading the clues.
Opening all safes unlocks the "No Safe is Safe" achievement / trophy.
