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Harsh Medicine, Pillars of Eternity II: Deadfire Quest

Walkthrough for the quest Harsh Medicine in the game Pillars of Eternity II: Deadfire. This page covers all main objectives, key steps, or helpful tips to guide you through the quest smoothly. Whenever possible, the guide points out locations for key items and details interactions with NPCs, among other tips. To ensure maximum clarity, in-game screenshots are included for easy-to-follow visual guidance.

  1. Guides for Gamers
  2. Pillars of Eternity II: Deadfire Game Guide
  3. Quests
  4. Harsh Medicine
Quests Maps World Map Vilario's Rest Port Maje Engwithan Digsite Neketaka, Queen's Berth Neketaka, The Gullet Neketaka, Periki's Overlook Neketaka, Serpent's Crown Neketaka, The Sacred Stair Neketaka, The Brass Citadel Tikawara Poko Kohara Ruins Fort Deadlight Dunnage Hasongo Crookspur Ori o Koīki Sayuka Motare o Kōzi Bekarna's Observatory Ashen Maw Pāhowane Splintered Reef Oathbinder's Sanctum Harbingers' Watch POIs More

Quest Group: Side Quests

Start location: Neketaka

Several Roparu in the Gullet have fallen ill with drowner's lung, a deadly and contagious disease. Pitli, a priestess from the Children of the Dawnstars, is caring for them in secret and needs medicine.

Note: Currently, this page contains raw quest data only. I know that it is not much, and I will try to update it with more valuable information as soon as possible.

Related points of interest

Icon of NPC Pitli Neketaka, The Gullet

Quest stages of Harsh Medicine

1. Go to Delver's Row in the Gullet.

Pitli thinks I could find the medicine she needs on Delver's Row.

Updates:

Pitli doesn't know how to reach Delver's Row, but the people that hang around the tavern might.

2. Find drowner's lung medicine on Delver's Row.

Delver's Row is bustling with shops and suspicious characters. One of them is bound to have the medicine Pitli needs.

Updates:

Ernezzo is rumored to have the medicine.

Ernezzo promised to give me the medicine if I kill the Spindle Man, another Delver's Row merchant.

Some of Ernezzo's gang leave his shop at night to go drink. It will be lightly guarded then.

The Spindle Man proposed that I kill Ernezzo instead. It promised me lower prices in return.

The Spindle Man mentioned a secret entrance to Ernezzo's storeroom. I can sneak in from the wooden catwalk east of his shop.

The Spindle Man is no more.

Rust will eliminate Ernezzo for me.

I've hired Rust to kill the Spindle Man.

Ernezzo is dead.

3. Give the drowner's lung medicine to Pitli in her home in the Gullet.

I have the medicine Pitli needs. She and the sick Roparu are waiting for it at her home in the Gullet.

Updates:

I stole the medicine from Ernezzo.

I killed Ernezzo and took the medicine.

4. Endings

I informed on the sick Roparu. Pitli and her charges were banished to the Old City.

I gave the medicine to Pitli. She and the sick Roparu are recovering.

Someone critical to this quest has died.