Safe Houses are special locations after unlocking which you will be able to use a mirror or an armory located there. To unlock them you must kill all enemies around it.
Safe Houses
Locations on Vaas' Mind
1
Beach Safe House
Difficulty: 2
2Jungle Safe House
Difficulty: 3
3The Compound
Starting location, you don't have to take it over.
4Volcanic Safe House
Difficulty: 2
Locations on Pagan's Mind
5Country Safe House
Difficulty: 2
6Lakeside Safe House
Difficulty: 2
7Mountain Safe House
Difficulty: 2
Locations on Father's Mind
8Cliffside Safe House
Difficulty: 2
9Hilltop Safe House
Difficulty: 2
10Valley Safe House
Difficulty: 2